SCHEMBL28201560

SCHEMBL28201560

FCCCCCc1c(F)cccc1F

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.45
DAO P14920 1/20 0.37
MPO P05164 3/20 0.36
SLC6A4 P31645 3/20 0.36
GAA P10253 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4E B2RXH2 2/20 0.33
GLS O94925 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAOA P21397 1/20 0.32
ACHE P22303 1/20 0.32
HTR2A P28223 1/20 0.32
NOS2 P35228 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5734084 0.81 TAAR1 (0.54) TAAR1DAOMPOSLC6A4GAA
SCHEMBL18006940 0.80 TAAR1 (0.39) TAAR1DAOMPOSLC6A4GAA
SCHEMBL23789712 0.80 MEN1 (0.51) SLC6A4SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL21312981 0.77 MEN1 (0.49) TAAR1SMN1; SMN2MEN1KMT2AKDM4E
SCHEMBL18378627 0.77 TAAR1 (0.41) TAAR1DAOMPOSLC6A4GAA
SCHEMBL7701701 0.77 TAAR1 (0.52) TAAR1DAOGAASMN1; SMN2KDM4E
SCHEMBL6085227 0.75 TAAR1 (0.71) TAAR1DAOMPOSLC6A4GAA
SCHEMBL97549 0.75 DAO (0.37) TAAR1DAOGAASMN1; SMN2MEN1
SCHEMBL97550 0.75 DAO (0.37) TAAR1DAOGAASMN1; SMN2MEN1
SCHEMBL6130256 0.74 TAAR1 (0.42) TAAR1DAOMPOSLC6A4GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104817438-B A kind of alkylation of fluorine-containing aryl halide 上海万溯化学有限公司 2018-01-16 CN disclosed
CN-104817438-A Alkylation method of fluorine-containing aryl halid SHANGHAI WANSHUO CHEMICAL CO LTD 2015-08-05 CN disclosed