Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26981146 | 0.82 | MCL1 (0.75) | MCL1MAOAKMT2AKDM4EMEN1 | |
| SCHEMBL27786187 | 0.81 | PTPN1 (0.58) | MCL1AKR1C2AKR1C1ACMSDALDH1A1 | |
| SCHEMBL28201890 | 0.80 | TDP1 (0.53) | MCL1KMT2AKDM4EMEN1TDP1 | |
| SCHEMBL27639373 | 0.80 | MCL1 (0.57) | MCL1MAOAKMT2AKDM4EMEN1 | |
| SCHEMBL2796864 | 0.79 | MCL1 (0.53) | MCL1MAOAMEN1MAP4K4PLK4 | |
| SCHEMBL28479099 | 0.79 | MCL1 (1.00) | MCL1MAOAKMT2AKDM4EMEN1 | |
| SCHEMBL28201920 | 0.79 | AKR1C2 (0.48) | MCL1KMT2AKDM4EMEN1AKR1C2 | |
| SCHEMBL27786189 | 0.77 | ACMSD (0.53) | MCL1KMT2AKDM4EMEN1TDP1 | |
| SCHEMBL27692105 | 0.77 | POLB (0.51) | MCL1KMT2AKDM4EMEN1TDP1 | |
| SCHEMBL27846422 | 0.77 | KMT2A (0.59) | MCL1KMT2AKDM4EMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164113-B | Pyrroloamide inhibitors | 艾伯维公司 | 2018-03-02 | — | — | CN | claimed |
| CN-105164113-B | Pyrroloamide inhibitors | 艾伯维公司 | 2018-03-02 | — | — | CN | disclosed |