Acetic Acid

Acetic Acid

SCHEMBL28201953

CC(=O)O.CC(C)CC(N)C(=O)OC(C)(C)C.Cl

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 known ✓ P29475 2/20 0.36
NOS3 known ✓ P29474 1/20 0.36
NOS2 known ✓ P35228 1/20 0.36
SLC7A5 Q01650 2/20 0.48
SLC1A3 P43003 2/20 0.39
SLC1A2 P43004 2/20 0.39
CTSL P07711 1/20 0.37
CTSB P07858 1/20 0.37
CTSS P25774 1/20 0.37
CTSK P43235 1/20 0.37
PSMB5 P28074 1/20 0.36
POLB P06746 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ANPEP P15144 2/20 0.34
RNPEP Q9H4A4 2/20 0.34
DNPEP Q9ULA0 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL953367 0.94 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2CTSLCTSB
Hydrochloric Acid SCHEMBL3937498 0.94 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2CTSLCTSB
Hydrochloric Acid SCHEMBL8319401 0.94 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2CTSLCTSB
Hydrochloric Acid SCHEMBL953366 0.94 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2CTSLCTSB
SCHEMBL66233 0.93 SLC7A5 (0.50) SLC7A5SLC1A3SLC1A2CTSLCTSB
SCHEMBL2541315 0.93 SLC7A5 (0.50) SLC7A5SLC1A3SLC1A2CTSLCTSB
SCHEMBL66234 0.93 SLC7A5 (0.50) SLC7A5SLC1A3SLC1A2CTSLCTSB
Water SCHEMBL27480998 0.91 SLC7A5 (0.48) SLC7A5SLC1A3SLC1A2CTSLCTSB
Hydrochloric Acid SCHEMBL14152512 0.89 SLC7A5 (0.47) SLC7A5SLC1A3SLC1A2CTSLCTSB
Hydrochloric Acid SCHEMBL20243055 0.85 NOS1 (0.38) SLC7A5SLC1A3SLC1A2NOS1NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107635989-A Benzimidizole derivatives as bromine domain inhibitor 葛兰素史克知识产权开发有限公司 2018-01-26 CN disclosed