SCHEMBL28205359

SCHEMBL28205359

O=C(O)[C@@H]1C[C@H]2CNC[C@H]2C1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 6/20 0.60
CHRNA4 P43681 6/20 0.60
CHRNA7 P36544 5/20 0.60
CHRNB4 P30926 5/20 0.60
CHRNA3 P32297 5/20 0.60
CYP2D6 P10635 3/20 0.44
CYP1A2 P05177 2/20 0.44
ALOX15 P16050 2/20 0.44
CYP2C19 P33261 2/20 0.44
SLC1A3 P43003 1/20 0.44
SLC1A2 P43004 1/20 0.44
SLC1A1 P43005 1/20 0.44
TSHR P16473 3/20 0.44
PMP22 Q01453 2/20 0.44
GABRP O00591 1/20 0.44
GABRD O14764 1/20 0.44
GABRA1 P14867 1/20 0.44
GABRB1 P18505 1/20 0.44
GABRG2 P18507 1/20 0.44
GABRB3 P28472 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28205361 1.00 CHRNB2 (0.60) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL31170446 1.00 CHRNB2 (0.60) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL2990754 1.00 CHRNB2 (0.60) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL27297131 0.81 CHRNB2 (0.52) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL15583555 0.78 CHRNB2 (0.48) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
Oxalic Acid SCHEMBL31075306 0.78 CHRNB2 (0.52) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL8256069 0.78 CYP2D6 (0.54) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL1117719 0.78 CYP2D6 (0.54) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL42967 0.77
SCHEMBL18460280 0.77 CYP2C19 (0.43) CYP2D6CYP1A2ALOX15CYP2C19SLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107849047-B Biphenyl derivative, preparation method and medical application thereof 四川海思科制药有限公司 2021-01-15 CN disclosed
CN-107849047-A Biphenyl derivative, preparation method and medical application thereof 四川海思科制药有限公司 2018-03-27 CN disclosed