Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84556 | 0.80 | ADORA2A (0.43) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL2661889 | 0.80 | JAK2 (0.55) | HTR1DGSK3BKDM4EGAAPDPK1 | |
| SCHEMBL12120600 | 0.80 | HTR1D (0.41) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL14737373 | 0.79 | HTR1D (0.40) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL21095943 | 0.79 | HTR1D (0.40) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL14827507 | 0.79 | HTR1D (0.40) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL17828603 | 0.76 | HTR1D (0.41) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL21017808 | 0.76 | HTR1D (0.38) | HTR1DHTR1BKIF11GSK3BKDM4E | |
| SCHEMBL6598584 | 0.73 | PRKAG1 (0.55) | GSK3BKDM4EGAAEIF4A3DYRK1A | |
| SCHEMBL22888210 | 0.72 | GSK3B (0.48) | HTR1DGSK3BKDM4EGAAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849023-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2018-03-27 | — | — | CN | disclosed |