Sugi Predict

Sugi Predict / Compounds / SCHEMBL2820672

SCHEMBL2820672

SCHEMBL2820672

COc1ccccc1-c1cnc2c(OC)nc3ccccc3n12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 2/20 0.52
▸ PDE10A Q9Y233 2/20 0.52
▸ ADORA2A P29274 2/20 0.44
▸ LMNA P02545 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ HTT P42858 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ SMN1; SMN2 Q16637 3/20 0.41
▸ RAB9A P51151 2/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ FLT3 P36888 1/20 0.40
▸ BMX P51813 1/20 0.40
▸ IKBKB O14920 1/20 0.40
▸ PDGFRB P09619 1/20 0.39
▸ PDGFRA P16234 1/20 0.39
▸ PKM P14618 2/20 0.39
▸ GAA P10253 2/20 0.39
▸ LCK P06239 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2815660 0.90 PDE2A (0.46) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2814037 0.87 TP53 (0.43) PDE2APDE10AKDM4EHTTALDH1A1
SCHEMBL2819611 0.86 ADORA2A (0.55) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2819649 0.86 MAPT (0.42) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2818894 0.86 PDE2A (0.51) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2813904 0.84 PDE2A (0.49) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2817449 0.83 IKBKB (0.50) PDE2APDE10AADORA2ALMNAKDM4E
SCHEMBL2819621 0.80 FLT3 (0.47) ADORA2ALMNAKDM4EHTTNPSR1
SCHEMBL2817052 0.79 IKBKB (0.59) PDE2APDE10AADORA2AKDM4ENPSR1
SCHEMBL2817616 0.79 IKBKB (0.41) PDE2APDE10AADORA2AKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205602-B1 IMIDAZO[1,2-A]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS UNIV MONTPELLIER (FR) 2018-09-26 — — EP claimed
US-8378098-B2 Imidazol[1,2-α]quinoxalines and derivatives for the treatment of cancers UNIVERSITE DE MONTPELLIER I (FR) 2013-02-19 — — US claimed
US-20100249142-A1 IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS UNIVERSITE DE MONTPELLIER I 2010-09-30 — — US claimed
EP-2205602-B1 IMIDAZO[1,2-A]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS UNIV MONTPELLIER (FR) 2018-09-26 — — EP disclosed
US-8378098-B2 Imidazol[1,2-α]quinoxalines and derivatives for the treatment of cancers UNIVERSITE DE MONTPELLIER I (FR) 2013-02-19 — — US disclosed
US-20100249142-A1 IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS UNIVERSITE DE MONTPELLIER I 2010-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249142-A1 IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS IDH3A, NRAS, KRAS PDE2A 1129/4885PDE10A 2521/4885ADORA2A 1818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.