SCHEMBL28207671

SCHEMBL28207671

Nc1c(Cl)cc(OC=O)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
CYP3A4 P08684 1/20 0.46
CA1 P00915 4/20 0.41
CA2 P00918 4/20 0.41
CA9 Q16790 4/20 0.41
GAA P10253 3/20 0.33
KDM4E B2RXH2 2/20 0.33
GLA P06280 2/20 0.33
POLB P06746 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
APEX1 P27695 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HSD11B1 P28845 3/20 0.32
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28133119 0.79 CYP3A4 (0.45) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL18573171 0.76 ALDH1A1 (0.32) ALDH1A1
SCHEMBL27687299 0.75 NR4A1 (0.33)
SCHEMBL2088497 0.75 TSHR (0.42) CYP3A4MAPT
SCHEMBL15626625 0.75 ALDH1A1 (0.37) ALDH1A1CYP3A4GAAMEN1MAPT
SCHEMBL15358720 0.75 ALDH1A1 (0.32) ALDH1A1CYP3A4GAAMEN1MAPT
SCHEMBL95605 0.74 ALDH1A1 (0.46) ALDH1A1CYP3A4KDM4ETDP1APEX1
SCHEMBL29782248 0.74 ALDH1A1 (0.46) ALDH1A1CYP3A4KDM4ETDP1APEX1
SCHEMBL28276359 0.74 ALDH1A1 (0.37) ALDH1A1CYP3A4CA1CA2CA9
SCHEMBL943194 0.74 ALDH1A1 (0.55) ALDH1A1CYP3A4CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105542584-B A kind of thermal sensation fluorine carbon functional paint and preparation method containing azobenzene/carbon hybrid material 天津大学 2018-04-03 CN disclosed