Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.57 |
| ▸ | PDE5A | O76074 | 10/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30724679 | 0.80 | DYRK1A (0.53) | DYRK1ACLK4CLK1CLK2DYRK1B | |
| SCHEMBL27561188 | 0.80 | HDAC3 (0.52) | PDE5A | |
| SCHEMBL27590341 | 0.79 | SMN1; SMN2 (0.58) | DYRK1ACLK4PDE5A | |
| SCHEMBL17283029 | 0.77 | PDE5A (0.49) | DYRK1ACLK4PDE5ASLKKMT2A | |
| SCHEMBL16848004 | 0.77 | MEN1 (0.54) | PDE5ASLKMEN1KMT2AKDM1A | |
| SCHEMBL4975928 | 0.77 | HTR7 (0.60) | PDE5AMEN1KMT2AKDM1AMAOA | |
| SCHEMBL14805818 | 0.76 | GAA (0.51) | PDE5ASLKMEN1KMT2AKDM1A | |
| SCHEMBL17741919 | 0.76 | GAA (0.56) | DYRK1ACLK4PDE5ASLKKDM1A | |
| SCHEMBL25912163 | 0.76 | PLK1 (0.66) | PDE5AMEN1KMT2A | |
| SCHEMBL5544418 | 0.75 | MAPT (0.52) | PDE5ASLKMEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104487434-B | Double cyclosubstituted pyrimidines | 山东轩竹医药科技有限公司 | 2018-05-22 | — | — | CN | disclosed |