Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243962 | 0.97 | KDM4E (0.54) | KDM4ECA1CA2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL27814697 | 0.94 | KDM4E (0.52) | KDM4ECA1CA2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2592331 | 0.94 | KDM4E (0.52) | KDM4ECA1CA2ALDH1A1LMNA | |
| SCHEMBL30440853 | 0.87 | KDM4E (0.58) | KDM4ECA1CA2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9934025 | 0.85 | KDM4E (0.56) | KDM4ECA1CA2ALDH1A1LMNA | |
| Alcohol SCHEMBL2281519 | 0.84 | KDM4E (0.43) | KDM4ECA1CA2ALDH1A1LMNA | |
| SCHEMBL16733020 | 0.81 | — | — | |
| Piperidine SCHEMBL16798704 | 0.79 | CA2 (0.59) | KDM4ECA1CA2ALDH1A1LMNA | |
| SCHEMBL29868290 | 0.79 | KDM4E (0.48) | KDM4ECA1CA2ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL3986645 | 0.79 | KDM4E (0.39) | KDM4ECA1CA2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107980040-A | 1,3,4- oxadiazoles sulfamide derivative as 6 inhibitor of histone deacetylase enzyme and the medical composition containing it | 株式会社钟根堂 | 2018-05-01 | — | — | CN | disclosed |
| CN-106659700-A | Sulfur fluoride (VI) compound and preparation method thereof | 斯克里普斯研究所 | 2017-05-10 | — | — | CN | disclosed |