SCHEMBL28210969

SCHEMBL28210969

Cc1ccccc1Nc1ccc(N)c(-c2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 6/20 0.45
MAPK13 O15264 5/20 0.45
MAPK12 P53778 5/20 0.45
MAPK11 Q15759 5/20 0.45
MAPT P10636 4/20 0.44
GAA P10253 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 3/20 0.41
LMNA P02545 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
HSD17B10 Q99714 2/20 0.40
MAPK10 P53779 1/20 0.40
SMN1; SMN2 Q16637 4/20 0.39
TP53 P04637 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23875735 0.87 MAPT (0.44) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL9006076 0.85 MAPK14 (0.44) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL31426816 0.82 TDP1 (0.56) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL13973364 0.82 TDP1 (0.56) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL14351550 0.80 ALDH1A1 (0.52) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL28424029 0.79 MAPK14 (0.37) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL28741050 0.77 MAPT (0.48) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL3788714 0.76 ALDH1A1 (0.48) MAPK14MAPK13MAPK12MAPK11TDP1
SCHEMBL17858148 0.76 PTGER4 (0.49) MAPK14MAPK13MAPK12MAPK11MAPT
SCHEMBL17463726 0.75 MAPK13 (0.47) MAPK14MAPK13MAPK12MAPK11MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108226345-B A kind of method of BNST pollutant in detection environment 哈尔滨工业大学 2018-11-30 CN disclosed
CN-108051526-B A kind of method of PREPOD pollutants in detection environment 哈尔滨工业大学 2018-10-30 CN disclosed
CN-107957472-B A kind of method of BENPAT pollutants in detection environment 哈尔滨工业大学 2018-10-30 CN disclosed
CN-108226345-A A kind of method of BNST pollutants in detection environment 哈尔滨工业大学 2018-06-29 CN disclosed
CN-108051526-A A kind of method of PREPOD pollutants in detection environment 哈尔滨工业大学 2018-05-18 CN disclosed
CN-107957472-A A kind of method of BENPAT pollutants in detection environment 哈尔滨工业大学 2018-04-24 CN disclosed