5,6,7,8-Tetrahydroisoquinoline

5,6,7,8-Tetrahydroisoquinoline

SCHEMBL28211

c1cc2c(cn1)CCCC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 1.00
CHRNB2 P17787 3/20 0.64
CHRNA4 P43681 3/20 0.64
CYP11B1 P15538 1/20 0.47
CYP11B2 P19099 1/20 0.47
TSHR P16473 1/20 0.46
NOS3 P29474 2/20 0.40
NOS1 P29475 2/20 0.40
NOS2 P35228 2/20 0.40
CHRM2 P08172 2/20 0.37
CHRM3 P20309 2/20 0.37
CHRM1 P11229 1/20 0.37
CHRNA7 P36544 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4077470 0.97 SIGMAR1 (0.95) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL12524319 0.97 SIGMAR1 (0.95) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL20682524 0.97 SIGMAR1 (0.95) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL19840372 0.97 SIGMAR1 (0.95) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL2388666 0.95
SCHEMBL29518090 0.95
SCHEMBL8348679 0.89
5,6,7,8-Tetrahydroisoquinoline SCHEMBL27987029 0.84 SIGMAR1 (0.70) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2
SCHEMBL13763083 0.80
5,6,7,8-Tetrahydroisoquinoline SCHEMBL28323135 0.78 SIGMAR1 (0.61) SIGMAR1CHRNB2CHRNA4CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4815 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624045-B2 Condensed cyclic compound, organic light-emitting device including the same, and electronic apparatus including the organic light-emitting device SAMSUNG ELECTRONICS CO., LTD. (KR) 2026-05-12 US claimed
EP-3985750-B1 LIGHT-EMITTING DEVICE AND APPARATUS INCLUDING THE SAME SAMSUNG DISPLAY CO LTD (KR) 2026-04-29 EP claimed
EP-3587427-B1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND APPARATUS INCLUDING THE ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2026-04-29 EP claimed
US-12606581-B2 Organometallic compound, organic light-emitting device including the same, and diagnostic composition including the organometallic compound SAMSUNG DISPLAY CO., LTD. (KR) 2026-04-21 US claimed
US-12598915-B2 Condensed cyclic compound, light-emitting device including the condensed cyclic compound, and electronic apparatus including the light-emitting device SAMSUNG DISPLAY CO., LTD. (KR) 2026-04-07 US claimed
US-20260096344-A1 LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, ELECTRONIC APPARATUS INCLUDING THE LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE INCLUDING THE LIGHT-EMITTING DEVICE, AND THE HETEROCYCLIC COMPOUND SAMSUNG DISPLAY CO LTD (KR) 2026-04-02 US claimed
EP-4719021-A1 LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, ELECTRONIC APPARATUS INCLUDING THE LIGHT-EMITTING DEVICE, AND THE HETEROCYCLIC COMPOUND Samsung Display Co., Ltd. (KR) 2026-04-01 EP claimed
US-20260090192-A1 LIGHT-EMITTING DEVICE INCLUDING ORGANOMETALLIC COMPOUND, ELECTRONIC APPARATUS AND ELECTRONIC DEVICE INCLUDING THE LIGHT-EMITTING DEVICE, AND THE ORGANOMETALLIC COMPOUND SAMSUNG DISPLAY CO LTD (KR) 2026-03-26 US claimed
US-20260090191-A1 LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, ELECTRONIC APPARATUS INCLUDING THE LIGHT-EMITTING DEVICE, AND THE HETEROCYCLC COMPOUND SAMSUNG DISPLAY CO., LTD. (KR) 2026-03-26 US claimed
US-20260082805-A1 ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2026-03-19 US claimed
EP-0650961-B1 Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments HOECHST AG (DE) 1997-03-05 EP claimed
EP-0714292-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE INC (US) 1996-10-09 EP claimed
CN-1126203-A Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals HOECHST AG (DE) 1996-07-10 CN claimed
EP-0714292-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE, INC. (US) 1996-06-05 EP claimed
EP-0661269-A1 Substituted heterocyclic carboxylic acid amides, their preparation and their use as medicaments HOECHST AKTIENGESELLSCHAFT (DE) 1995-07-05 EP claimed
EP-0650961-A1 Substituted heterocyclic carboxylic acid amides, their preparation, and their use as medicaments HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-03 EP claimed
EP-0650960-A1 Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-03 EP claimed
WO-1995000131-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) 1995-01-05 WO claimed
EP-0189287-B1 NOVEL B-LACTAM ANTIBIOTICS NIPPON PHARMACEUTICAL DEVELOPMENT INSTITUTE COMPANY LIMITED (JP) 1992-12-16 EP claimed
EP-0189287-A2 Novel B-lactam antibiotics NIPPON PHARMACEUTICAL DEVELOPMENT INSTITUTE COMPANY LIMITED (JP) 1986-07-30 EP claimed