Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 16/20 | 0.64 |
| ▸ | TOP2A | P11388 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821155 | 0.94 | KCNH2 (0.68) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL2819606 | 0.93 | KCNH2 (0.67) | KCNH2TOP2ASLC2A1 | |
| Benzoic Acid SCHEMBL2822649 | 0.93 | KCNH2 (0.56) | KCNH2TOP2ASLC2A1 | |
| SCHEMBL2821273 | 0.90 | KCNH2 (0.69) | KCNH2TOP2ASLC2A1 | |
| SCHEMBL2822290 | 0.90 | KCNH2 (0.58) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL2824637 | 0.89 | KCNH2 (0.68) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL2819372 | 0.89 | KCNH2 (0.68) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL2820309 | 0.89 | KCNH2 (0.57) | KCNH2TOP2ASLC2A1 | |
| SCHEMBL2818725 | 0.87 | KCNH2 (0.59) | KCNH2TOP2ASLC2A1 | |
| SCHEMBL3604475 | 0.87 | KCNH2 (0.67) | KCNH2TOP2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041145-B1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | claimed |
| US-20100004230-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | claimed |
| EP-2041145-B1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |
| US-20100004230-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| US-20100004230-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| WO-2008003690-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004230-A1 | AZATRICYCLIC COMPOUNDS AND THEIR USE | AADAC, AZI2, NNMT | KCNH2 2592/4885TOP2A 9/4885SLC2A1 4507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.