Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9438 | 0.89 | CYP1A2 (0.48) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| Morpholine SCHEMBL14720242 | 0.88 | CYP1A2 (0.36) | CYP1A2IDO1METAP2KEAP1HTR7 | |
| SCHEMBL28309054 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| SCHEMBL31519384 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| SCHEMBL514705 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| SCHEMBL30636164 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| SCHEMBL842040 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| Ammonia Solution, Strong SCHEMBL29843017 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| Phosphine SCHEMBL28114703 | 0.87 | CYP1A2 (0.47) | CYP1A2IDO1METAP2KEAP1RAB9A | |
| SCHEMBL16800868 | 0.85 | CYP1A2 (0.45) | CYP1A2IDO1METAP2KEAP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107935933-A | A kind of preparation method of 5 piperazinyl, 3 methyl, 1 Phenylpyrazole | 江西开元生物医药科技有限公司 | 2018-04-20 | — | — | CN | disclosed |