SCHEMBL28212973

SCHEMBL28212973

[CH2]c1cnc(CC#N)cn1

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3680387 0.86 MEN1 (0.54) MEN1MAPTKMT2A
SCHEMBL25826358 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL30736092 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL23171261 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL14920779 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL25231594 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL2644333 0.74 MEN1 (0.44) MEN1MAPTKMT2A
SCHEMBL30736216 0.71 SIRT6 (0.43) MEN1MAPTKMT2A
SCHEMBL292560 0.70
SCHEMBL28210137 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922316-A Fto inhibitor 北京生命科学研究所 2018-04-17 CN disclosed