Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.50 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27660917 | 0.90 | TLR8 (0.63) | PDE10ATLR8MYCKMT2APSMB5 | |
| SCHEMBL27660900 | 0.89 | TLR8 (0.64) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL27640113 | 0.88 | TLR8 (0.62) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL27640115 | 0.88 | TLR8 (0.62) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL16198056 | 0.88 | TLR8 (0.62) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL27640114 | 0.88 | TLR8 (0.62) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL28062696 | 0.88 | TLR8 (0.62) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL20081370 | 0.86 | PDE10A (0.61) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL4915121 | 0.83 | PDE10A (0.53) | PDE10ATLR8MYCALDH1A1KDM4E | |
| SCHEMBL6290234 | 0.81 | TLR8 (0.48) | PDE10ATLR8MYCALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112521333-A | Synthesis method of chiral 2, 3-disubstituted tetrahydroquinoline derivative | 中国科学院大连化学物理研究所 | 2021-03-19 | — | — | CN | disclosed |
| CN-108017579-B | Method for synthesizing quinoline compound by oxidative dehydrogenation of tetrahydroquinoline compound under synergistic catalysis of visible light | 河南大学 | 2021-01-29 | — | — | CN | disclosed |
| CN-108017579-A | A kind of method of visible ray concerted catalysis Tetrahydroquinolinesas oxidative dehydrogenation synthesis of quinoline class compound | 河南大学 | 2018-05-11 | — | — | CN | disclosed |