Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122427 | 0.83 | — | — | |
| SCHEMBL14213341 | 0.83 | — | — | |
| SCHEMBL1558518 | 0.79 | CHRNA4 (0.37) | CHRNA4RAPGEF3RAPGEF4RAB9ACNR2 | |
| SCHEMBL1323514 | 0.76 | — | — | |
| SCHEMBL11166684 | 0.74 | — | — | |
| SCHEMBL826240 | 0.74 | — | — | |
| SCHEMBL28827221 | 0.74 | LMNA (0.50) | LMNAHPGDRAB9ANPC1POLB | |
| SCHEMBL11658293 | 0.73 | CHRNA4 (0.42) | CHRNA4CNR2ACACBAR | |
| Formaldehyde SCHEMBL1558516 | 0.73 | CHRNA4 (0.41) | CHRNA4RAPGEF3RAPGEF4LMNACNR2 | |
| SCHEMBL9114947 | 0.72 | CHRNA4 (0.45) | CHRNA4RAPGEF3RAPGEF4LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108064313-A | Compositions and methods for inhibiting gene expression of factor XII | 箭头药业股份有限公司 | 2018-05-22 | — | — | CN | disclosed |