Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | SCNN1A | P37088 | 9/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | GLA | P06280 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805324 | 0.79 | SCNN1A (0.63) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL31325583 | 0.79 | SCNN1A (0.63) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL11496167 | 0.78 | ALDH1A1 (0.65) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL3148174 | 0.78 | SCNN1A (0.56) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL28033914 | 0.77 | ALDH1A1 (0.51) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| Amiloride SCHEMBL27562 | 0.77 | SCNN1A (0.58) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL11528414 | 0.77 | SCNN1A (0.51) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| Amiloride SCHEMBL15517241 | 0.77 | SCNN1A (0.58) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL23337629 | 0.75 | SCNN1A (0.58) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD | |
| SCHEMBL31647638 | 0.75 | SCNN1A (0.58) | ALDH1A1SCNN1AHSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658876-A | The chloro- N- of 3,5- diamino -6- (N- (4- phenyl butyls) carbonamidine base) pyrazine -2- benzamide compounds | 帕里昂科学公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-108484513-A | It can be used for treating the chloro-pyrazine carboxamides derivatives of the disease as caused by mucous membrane aquation deficiency | 帕里昂科学公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-104995178-B | 3, 5-diamino-6-chloro-N- (N- (4-phenylbutyl) carbamimidoyl) pyrazine-2-carboxamide compounds | 帕里昂科学公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-105073717-B | Chloro-pyrazinecarboxamide derivatives useful for the treatment of diseases caused by insufficient hydration of the mucous membranes | 帕里昂科学公司 | 2018-05-22 | — | — | CN | disclosed |