SCHEMBL28217023

SCHEMBL28217023

COc1ccc(C(O)C(CO)NNC(=O)O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR88 Q9GZN0 1/20 0.44
NPY5R Q15761 1/20 0.42
CNR2 P34972 2/20 0.42
AOC3 Q16853 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
GAA P10253 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
LDHA P00338 1/20 0.40
TSHR P16473 2/20 0.39
LMNA P02545 2/20 0.39
CNR1 P21554 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MEN1 O00255 1/20 0.39
RAB9A P51151 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3112603 0.85 GPR88 (0.49) GPR88NPY5RCNR2AOC3L3MBTL1
SCHEMBL3112591 0.85 GPR88 (0.49) GPR88NPY5RCNR2AOC3L3MBTL1
SCHEMBL28157260 0.81 MEN1 (0.45) GPR88NPY5RCNR2AOC3ALDH1A1
SCHEMBL12406505 0.76 ATM (0.60) GPR88CNR2ALDH1A1TSHR
SCHEMBL836812 0.73 NPSR1 (0.48) GPR88NPY5RCNR2AOC3L3MBTL1
SCHEMBL6272410 0.72 PPARG (0.62) GPR88AOC3L3MBTL1ALDH1A1TDP1
SCHEMBL15674956 0.72 GPR88 (0.50) GPR88CNR2AOC3L3MBTL1ALDH1A1
SCHEMBL23100736 0.71 GPR88 (0.68) GPR88CNR2NPSR1MEN1KMT2A
SCHEMBL6256724 0.71 GPR88 (0.68) GPR88CNR2NPSR1MEN1KMT2A
SCHEMBL3014293 0.71 NPY5R (0.49) GPR88NPY5RCNR2GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107935983-A 2 amide groups propyl alcohol type glucosylceramide synthase inhibitor 简詹姆公司 2018-04-20 CN disclosed