Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | ELOVL1 | Q9BW60 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981553 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2CRHBPCRHR2TSHRNPC1 | |
| SCHEMBL15114915 | 0.94 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2TSHRNPC1 | |
| SCHEMBL19548104 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRNPC1RAB9ARECQL | |
| SCHEMBL207751 | 0.82 | CYP1A2 (0.41) | SMN1; SMN2CRHBPCRHR2TSHRNPC1 | |
| SCHEMBL12497703 | 0.82 | HRH4 (0.57) | TSHRHRH4ALDH1A1KDM4EHPGD | |
| SCHEMBL10272311 | 0.81 | CYP2C19 (0.63) | SMN1; SMN2CRHBPCRHR2NPC1RAB9A | |
| SCHEMBL14538234 | 0.81 | CYP1A2 (0.57) | HRH4ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL2272151 | 0.79 | CYP17A1 (0.39) | SMN1; SMN2CRHBPCRHR2TSHRNPC1 | |
| SCHEMBL15114895 | 0.79 | LMNA (0.49) | SMN1; SMN2TSHRL3MBTL1HRH4ALDH1A1 | |
| SCHEMBL11981591 | 0.78 | SMO (0.46) | TSHRL3MBTL1HRH4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101855-B | Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocycle | 贵州理工学院 | 2021-01-01 | — | — | CN | claimed |
| CN-108101855-B | Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocycle | 贵州理工学院 | 2021-01-01 | — | — | CN | disclosed |
| CN-108101855-B | Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocycle | 贵州理工学院 | 2021-01-01 | — | — | CN | disclosed |
| CN-108101855-B | Preparation method and application of amino acid ester compound containing 4-piperidyl-6-methylpyrimidine heterocycle | 贵州理工学院 | 2021-01-01 | — | — | CN | disclosed |
| CN-108101855-A | A kind of Preparation method and use of the amino acid esters compound of -6- of piperidyl containing 4- methylpyrimidine heterocycles | 贵州理工学院 | 2018-06-01 | — | — | CN | disclosed |