Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
| ▸ | BAX | Q07812 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422751 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| Hydrochloric Acid SCHEMBL21178220 | 0.98 | SMN1; SMN2 (0.58) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| Hydrochloric Acid SCHEMBL8296060 | 0.98 | SMN1; SMN2 (0.58) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL13833167 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL1974799 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL1393824 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL154268 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL10667505 | 0.98 | SMN1; SMN2 (0.56) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL22014102 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 | |
| SCHEMBL20565492 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2CHRM5CHRM3RAD52IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108079748-A | Hydroxypropylpiperazine class organic amine desulfurizer and its preparation method and application | 合肥工业大学 | 2018-05-29 | — | — | CN | disclosed |