Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537248 | 0.89 | DRD2 (0.53) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL12324832 | 0.85 | MAPT (0.53) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL28845517 | 0.83 | MAPT (0.46) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL764370 | 0.82 | MAPT (0.58) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL1670746 | 0.82 | MAPT (0.54) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL4541628 | 0.82 | CA12 (0.53) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL18089384 | 0.82 | MAPT (0.50) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL27725280 | 0.81 | MAPT (0.47) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL5547965 | 0.81 | MAPT (0.43) | MAPTKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10911695 | 0.79 | KDM4E (0.55) | MAPTKDM4EGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106687453-B | Tetrahydroquinoline derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-105189461-B | The dibasic 1- acyl groups -4- amino -1,2,3,4- tetrahydroquinoline derivatives of 2,3- and their purposes as bromine domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2018-05-15 | — | — | CN | disclosed |