Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Homoserine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 4/20 | 0.48 |
| ▸ | NOS3 known ✓ | P29474 | 3/20 | 0.48 |
| ▸ | NOS1 known ✓ | P29475 | 3/20 | 0.48 |
| ▸ | GSR | P00390 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homoserine SCHEMBL27743664 | 0.92 | GSR (0.54) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL28042341 | 0.92 | GSR (0.54) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL4944178 | 0.92 | GSR (0.59) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL29648 | 0.92 | — | — | |
| Homoserine SCHEMBL6447119 | 0.92 | GSR (0.59) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL6446994 | 0.92 | GSR (0.59) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL29649 | 0.92 | — | — | |
| Homoserine SCHEMBL60060 | 0.92 | — | — | |
| Homoserine SCHEMBL20299187 | 0.90 | SLC1A3 (0.52) | GSRCYP1A2GRM8GRM6GRIN2D | |
| Homoserine SCHEMBL23748103 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026516-A | Produced by the thio carboxylate dependence l-methionine of the albumen of fermentation | 赢创德固赛有限公司 | 2018-05-11 | — | — | CN | disclosed |