Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | DRD2 | P14416 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.59 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.54 |
| ▸ | HTR3B | O95264 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335802 | 0.98 | HTR1A (0.73) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL31561598 | 0.98 | HTR1A (0.73) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL28078181 | 0.98 | HTR1A (0.73) | HTR1AHTR2ADRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7927336 | 0.96 | HTR1A (0.71) | HTR1AHTR2ADRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7982587 | 0.96 | HTR1A (0.71) | HTR1AHTR2ADRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL7983458 | 0.90 | HTR1A (0.63) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL29432674 | 0.86 | HTR1A (0.58) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL404338 | 0.86 | HTR1A (0.58) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL3805551 | 0.85 | HTR1A (0.61) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL13563351 | 0.84 | HTR1A (0.69) | HTR1AHTR2ADRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108017659-A | Benzimidazole and thiazole carboxamides class compound and its application | 沈阳药科大学 | 2018-05-11 | — | — | CN | disclosed |