SCHEMBL28218317

SCHEMBL28218317

O=Cc1nc2ccc(C(F)(F)F)cc2s1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.59
SCN4A P35499 1/20 0.59
DYRK1A Q13627 2/20 0.52
ACP1 P24666 1/20 0.50
PPARA Q07869 1/20 0.49
CSNK1D P48730 12/20 0.47
CYP2D6 P10635 1/20 0.44
LRRK2 Q5S007 1/20 0.40
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18003518 0.88 EPHX2 (0.47) EPHX2SCN4ADYRK1AACP1PPARA
SCHEMBL31136533 0.87 DYRK1A (0.52) EPHX2SCN4ADYRK1AACP1
SCHEMBL21945689 0.84 MAPT (0.47) EPHX2SCN4ADYRK1APPARACSNK1D
SCHEMBL28367183 0.78 GFER (0.56) DYRK1ALRRK2MAPT
SCHEMBL31019504 0.78 GFER (0.56) DYRK1ALRRK2MAPT
SCHEMBL212708 0.77 DYRK1A (0.63) EPHX2SCN4ADYRK1AACP1CSNK1D
Cyanide SCHEMBL22130218 0.77 EPHX2 (0.55) EPHX2SCN4ADYRK1AACP1PPARA
SCHEMBL3641501 0.76 PPARA (0.61) EPHX2SCN4ADYRK1AACP1PPARA
SCHEMBL3075842 0.76 EPHX2 (0.67) EPHX2SCN4ADYRK1AACP1PPARA
SCHEMBL24992674 0.75 CA1 (0.58) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108101863-B Method for synthesizing benzothiazole-2-ketone derivative by using carbonyl sulfide and disulfide as raw materials 内蒙古工业大学 2022-01-25 CN disclosed
CN-108101863-A It is a kind of using carbonyl sulfur and disulphide as the method for Material synthesis benzothiazole -2- ketones derivants 内蒙古工业大学 2018-06-01 CN disclosed