Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 13/20 | 0.56 |
| ▸ | ACP1 | P24666 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | SCN4A | P35499 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683714 | 0.80 | DYRK1A (0.68) | DYRK1ACSNK1DACP1EPHX2SCN4A | |
| SCHEMBL2116732 | 0.80 | KDM4E (0.64) | DYRK1ACSNK1DACP1EPHX2SCN4A | |
| SCHEMBL8430853 | 0.80 | DYRK1A (0.68) | DYRK1ACSNK1DACP1EPHX2SCN4A | |
| SCHEMBL211725 | 0.79 | DYRK1A (0.65) | DYRK1ACSNK1DACP1SCN4ACSNK2A2 | |
| SCHEMBL3791611 | 0.78 | DYRK1A (0.78) | DYRK1ACSNK1DACP1CYP2D6LRRK2 | |
| SCHEMBL28878445 | 0.78 | DYRK1A (0.64) | DYRK1ACSNK1DACP1EPHX2SCN4A | |
| SCHEMBL29974674 | 0.78 | DYRK1A (0.64) | DYRK1ACSNK1DACP1EPHX2SCN4A | |
| SCHEMBL6191383 | 0.77 | DYRK1A (0.76) | DYRK1ACSNK1DACP1CYP2D6LRRK2 | |
| SCHEMBL25464674 | 0.77 | RAB9A (0.60) | DYRK1ACSNK1DCYP2D6LRRK2 | |
| SCHEMBL14189675 | 0.77 | NPC1 (0.61) | DYRK1AACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| EP-1620413-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004098494-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |