Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845948 | 0.89 | KDM4E (0.45) | KDM4EMAPK1MAP2K4MAPK6MAPKAPK5 | |
| SCHEMBL162796 | 0.81 | ESR1 (0.45) | KDM4EMAPK1MAP2K4MAPK6MAPKAPK5 | |
| SCHEMBL282278 | 0.80 | DHODH (0.40) | KDM4EMAPK1MAP2K4MAPK6DHODH | |
| SCHEMBL3911390 | 0.79 | KDM4E (0.50) | KDM4EMAPK1MAP2K4MAPK6MAPKAPK3 | |
| SCHEMBL2904601 | 0.79 | IGFBP3 (0.50) | KDM4EMAPK1MAP2K4MAPK6MAPKAPK5 | |
| SCHEMBL281875 | 0.76 | CHEK1 (0.42) | KDM4EMAPK1SLC6A2ALDH1A1HPGD | |
| SCHEMBL899555 | 0.76 | KDM4E (0.47) | KDM4ESLC6A2P2RY14PARP1MEN1 | |
| SCHEMBL22805613 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL13099484 | 0.76 | POLB (0.45) | MAP2K4DHODHKMOALDH1A1HPGD | |
| SCHEMBL20784 | 0.75 | DHODH (0.51) | KDM4EMAPK1MAP2K4MAPK6MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957087-B2 | Heterocyclic substituted acardite derivate and application thereof | Jiangsu Provincial Institute of Materia Medica Co., Ltd. (CN) | 2015-02-17 | — | — | US | disclosed |
| EP-2428506-B1 | HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF | NANJING LUYESIKE PHARMACEUTICAL CO LTD (CN) | 2014-03-05 | — | — | EP | disclosed |
| CN-101671301-B | Heterocyclic substituent acardite derivate and application thereof | JIANGSU PROVINCIAL INST OF MATERIA MEDICA CO LTD | 2014-02-26 | — | — | CN | disclosed |
| EP-2428506-A1 | HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF | Jiangsu Provincial Institute Of Materia Medica Co. (CN) | 2012-03-14 | — | — | EP | disclosed |
| US-20120053192-A1 | Heterocyclic Substituted Acardite Derivate and Application Thereof | NANJING LUYESIKE PHARMACEUTICAL CO., LTD. (CN) | 2012-03-01 | — | — | US | disclosed |
| CN-101671301-A | Heterocyclic substituent acardite derivate and application thereof | JIANGSU PROVINCIAL INST OF MAT | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053192-A1 | Heterocyclic Substituted Acardite Derivate and Application Thereof | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, IDH1, CA7 | KDM4E 1618/4885MAPK1 3213/4885MAP2K4 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.