IGFBP3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6014808	1.00	20/20
SCHEMBL11374392	0.64	13/20
SCHEMBL9450837	0.59	11/20
SCHEMBL7591756	0.50	11/20
SCHEMBL9319269	0.52	9/20
SCHEMBL9424897	0.41	8/20
SCHEMBL2908228	0.43	7/20
SCHEMBL9327979	0.52	6/20
SCHEMBL9319235	0.45	5/20
SCHEMBL2904707	0.43	5/20
Papaveroline (SCHEMBL564044)	0.57	4/20
SCHEMBL21628513	0.52	4/20
SCHEMBL2904601	0.50	4/20
SCHEMBL4768998	0.49	4/20
SCHEMBL129810	0.47	4/20
SCHEMBL21979549	0.46	4/20
SCHEMBL1990776	0.44	4/20
SCHEMBL8834235	0.44	4/20
SCHEMBL21628626	0.43	4/20
SCHEMBL351902	0.43	4/20

Clinical trials — most relevant to IGFBP3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Cytokines on Growth of Children With Chronic Kidney Failure	PHASE4	SUSPENDED
Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne Vulgaris	PHASE4	COMPLETED
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia	PHASE4	COMPLETED
Effects of Oral vs. Non-oral Contraceptives on the GH/IGF-1 Axis	PHASE4	COMPLETED
Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI	PHASE2	COMPLETED
Effect of Continuous GHRP-3 Infusion at on GH-IGF-I System, Blood Pressure, Glucose, and Insulin Resistance	PHASE1/PHASE2	WITHDRAWN
IGF-1/IGFBP3 Prevention of Retinopathy of Prematurity	PHASE2	COMPLETED
Study Assessing Potential Predictive Tumor Markers in Metastatic Colorectal Cancer	PHASE2	COMPLETED
Green Tea and Reduction of Breast Cancer Risk	PHASE2	COMPLETED
Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy	PHASE1/PHASE2	COMPLETED
Defined Green Tea Catechins in Treating Patients With Prostate Cancer Undergoing Surgery to Remove the Prostate	PHASE1	COMPLETED
Estradiol-Receptor Blockade in Older Men and Women	PHASE1	COMPLETED
AMG-479 in Treating Patients With Advanced Solid Tumors or Non-Hodgkin Lymphoma	PHASE1	COMPLETED
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK	nan	COMPLETED
Prognostic Value of Protein IMP3 Expression in Cervical Cancer	nan	COMPLETED
Assessment of the Diagnostic Role of Serum Insulin-like Growth Factor Binding Protein-3 as a Potential Biomarker for Colorectal Cancer (CRC) in Egypt	nan	NOT_YET_RECRUITING
Follow-up to Adult Height of a Cohort of Subjects Born Small for the Gestational Age and Treated With Growth Hormone	nan	COMPLETED
Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation	nan	UNKNOWN
Epidemiology of Insulin Growth Factor (IGF) and Cardiovascular Events	nan	COMPLETED
Atrial Fibrillation in Relationship to Plasma Biomarkers	nan	UNKNOWN
The Effect of Transcatheter VSD Closure on Children's Appetite, Hormones and Growth	nan	COMPLETED
Role of Biomarkers in Endometrial Cancer Recurrence in Samples From Patients With Stage II, Stage III, or Stage IV Endometrial Cancer	nan	UNKNOWN
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.	nan	COMPLETED
IGF-I Induced Muscle Glucose Uptake and Interstitial IGF-I Concentrations	nan	COMPLETED
Measurement of Outcome of Surgical Treatment in Patients With Acromegaly	nan	UNKNOWN
Biomarkers Related to Bone in Pediatric Gaucher Disease	nan	UNKNOWN
Low-Fat Fish Oil Diet for Prostate Cancer Prevention	nan	COMPLETED
Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02	nan	COMPLETED
Soy-Based Meal Replacement in Helping Women With Stage I, Stage II, or Stage III Breast Cancer in Complete Remission Lose Weight	nan	COMPLETED
Patient Fitness and Body Composition During Hematopoietic Stem Cell Transplantation	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a IGFBP3 binder may also engage these)

Protein	Name	Similarity
P47878	—	1.000	P47878 →
P20959	—	1.000	P20959 →
P15473	—	0.996	P15473 →
P47877	—	0.991	P47877 →
P47879	—	0.991	P47879 →
P49705	—	0.989	P49705 →
P24853	—	0.989	P24853 →
IGFBP5	Insulin-like growth factor-binding protein 5	0.988	landscape →
P16611	—	0.988	P16611 →
A4IIA2	—	0.988	A4IIA2 →
P21744	—	0.988	P21744 →
Q5XHC5	—	0.987	Q5XHC5 →
Q29400	—	0.987	Q29400 →
P12843	—	0.987	P12843 →
Q05716	—	0.987	Q05716 →
Q75ZP3	—	0.987	Q75ZP3 →
Q28985	—	0.987	Q28985 →
IGFBP2	Insulin-like growth factor-binding protein 2	0.986	landscape →
P24594	—	0.986	P24594 →
IGFBP4	Insulin-like growth factor-binding protein 4	0.985	landscape →
Q6Q484	—	0.985	Q6Q484 →
P24854	—	0.985	P24854 →
P21743	—	0.985	P21743 →
P13384	—	0.984	P13384 →
P47876	—	0.983	P47876 →
P24591	—	0.983	P24591 →
Q05717	—	0.983	Q05717 →
Q07079	—	0.980	Q07079 →
IGFBP1	Insulin-like growth factor-binding protein 1	0.980	landscape →
P19336	—	0.976	P19336 →