Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927645 | 0.80 | HDAC6 (0.49) | MAP4K4HRH4HRH3HDAC6DYRK1A | |
| SCHEMBL28219641 | 0.80 | MAP4K4 (0.47) | MAP4K4HRH4HRH3HDAC6DYRK1A | |
| SCHEMBL28543291 | 0.80 | MAP4K4 (0.53) | MAP4K4HRH4HRH3HDAC6DYRK1A | |
| SCHEMBL13806026 | 0.73 | DYRK1A (0.55) | MAP4K4HRH4HRH3DYRK1AMAPK8 | |
| SCHEMBL13806029 | 0.73 | DYRK1A (0.55) | MAP4K4HRH4HRH3DYRK1AMAPK8 | |
| SCHEMBL10145970 | 0.73 | KDM4E (0.51) | DYRK1AADRA1B | |
| SCHEMBL12663042 | 0.72 | KDM4E (0.49) | MAP4K4HRH4HRH3PDE10A | |
| SCHEMBL12487715 | 0.72 | DYRK1A (0.54) | MAP4K4HRH4HRH3DYRK1AJAK2 | |
| SCHEMBL16991350 | 0.71 | DYRK1A (0.45) | MAP4K4HRH4HRH3HDAC6DYRK1A | |
| SCHEMBL19251255 | 0.71 | DYRK1A (0.47) | MAP4K4HRH4HRH3HDAC6DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108135175-A | Bicyclic compounds and their use for inhibition of SUV39H2 | 肿瘤疗法科学股份有限公司 | 2018-06-08 | — | — | CN | disclosed |