Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL4465186 | 0.95 | HIF1A (0.33) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL28829648 | 0.95 | HIF1A (0.33) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL23932515 | 0.92 | HIF1A (0.32) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL27740510 | 0.92 | HIF1A (0.32) | HIF1AMAPTPDE4AKDR | |
| Aziridine SCHEMBL17610175 | 0.92 | — | — | |
| Piperazine SCHEMBL27802271 | 0.91 | TSHR (0.38) | — | |
| Piperazine SCHEMBL27410207 | 0.89 | — | — | |
| Benzene SCHEMBL487381 | 0.87 | — | — | |
| Benzene SCHEMBL28126191 | 0.87 | — | — | |
| Benzene SCHEMBL28097781 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164533-A | Compound of piperazine triazole structure of amino-contained benzene and application thereof | 广东赛博科技有限公司 | 2018-06-15 | — | — | CN | disclosed |