Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL4465186 | 1.00 | HIF1A (0.33) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL23932515 | 0.97 | HIF1A (0.32) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL27740510 | 0.97 | HIF1A (0.32) | HIF1AMAPTPDE4AKDR | |
| Aziridine SCHEMBL17610175 | 0.97 | — | — | |
| Piperazine SCHEMBL28222398 | 0.95 | HIF1A (0.30) | HIF1AMAPTPDE4AKDR | |
| Piperazine SCHEMBL27410207 | 0.89 | — | — | |
| Piperazine SCHEMBL28111960 | 0.89 | — | — | |
| SCHEMBL28194594 | 0.88 | — | — | |
| Piperidine SCHEMBL23725007 | 0.87 | ALDH1A1 (0.43) | — | |
| SCHEMBL15544478 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104478860-B | Diamantane (obsolete) tetrazole derivant, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104530009-B | Amantadine tetrazole derivant, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104478777-B | A kind of containing nitro diamantane (obsolete) with the derivant of amide structure, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104478861-B | A kind of nitro diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-104447703-B | A kind of nitro diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-104447704-B | A kind of itrile group diamantane (obsolete) tetrazotized zole compound, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-104478859-B | A kind of hydroxyadamantane tetrazotized zole compound, Preparation Method And The Use | 佛山市赛维斯医药科技有限公司 | 2016-07-27 | — | — | CN | disclosed |