Alpha-Naphthylisocyanate

Alpha-Naphthylisocyanate

SCHEMBL28223340

N=C=O.O=C=NCCCCCN=C=O.O=C=Nc1cccc2ccccc12

nearest known ligand 0.45

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.45
CYP1A2 P05177 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
ABCB11 O95342 1/20 0.45
ALDH1A1 P00352 1/20 0.45
NR3C1 P04150 1/20 0.45
ADRA2A P08913 1/20 0.45
ADORA3 P0DMS8 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
ADRA2C P18825 1/20 0.45
MAOA P21397 1/20 0.45
DRD1 P21728 1/20 0.45
SLC6A4 P31645 1/20 0.45
HTR2B P41595 1/20 0.45
CCR2 P41597 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28070263 0.86 CYP3A4 (0.46) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
Alpha-Naphthylisocyanate SCHEMBL27296117 0.86 CYP1A2 (0.58) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
SCHEMBL3814088 0.85 CYP3A4 (0.47) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
Alpha-Naphthylisocyanate SCHEMBL374 0.81 CYP1A2 (0.64) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
Alpha-Naphthylisocyanate SCHEMBL29400034 0.81 CYP1A2 (0.64) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
Alpha-Naphthylisocyanate SCHEMBL5505170 0.80 CYP3A4 (0.45) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
Alpha-Naphthylisocyanate SCHEMBL3333508 0.79 CYP1A2 (0.62) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
1,6-Hexanediol SCHEMBL7029490 0.78 CYP3A4 (0.39) CYP3A4
Alpha-Naphthylisocyanate SCHEMBL3338004 0.78 CYP1A2 (0.60) CYP3A4CYP1A2TDP1ABCB11ALDH1A1
SCHEMBL9195080 0.78 CYP3A4 (0.50) CYP3A4CYP1A2TDP1ABCB11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137762-A Actinic energy ray curable resion composition and its manufacturing method 日本合成化学工业株式会社 2018-06-08 CN disclosed