Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | CCR2 | P41597 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Naphthylisocyanate SCHEMBL374 | 0.96 | CYP1A2 (0.64) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| Alpha-Naphthylisocyanate SCHEMBL29400034 | 0.96 | CYP1A2 (0.64) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| Alpha-Naphthylisocyanate SCHEMBL3333508 | 0.94 | CYP1A2 (0.62) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| Alpha-Naphthylisocyanate SCHEMBL27296117 | 0.90 | CYP1A2 (0.58) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| Alpha-Naphthylisocyanate SCHEMBL11673586 | 0.85 | CYP3A4 (0.49) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL22210 | 0.83 | CYP3A4 (0.62) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL29370250 | 0.83 | CYP3A4 (0.62) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL5971050 | 0.81 | CYP3A4 (0.47) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| SCHEMBL9229488 | 0.79 | CYP3A4 (0.54) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 | |
| Alpha-Naphthylisocyanate SCHEMBL9443219 | 0.79 | ALDH1A1 (0.45) | CYP1A2ALDH1A1CYP3A4HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144698-A1 | SUBSTITUTED AZETIDINONES | DAIAMED (US) | 2010-06-10 | — | — | US | disclosed |
| US-20090143351-A1 | SUBSTITUTED AZETIDINONES | DAIAMED (US) | 2009-06-04 | — | — | US | disclosed |
| US-7501404-B2 | Substituted azetidinones | DAIMED (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1871741-A2 | SUBSTITUTED AZETIDINONES | Daiamed, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20070105832-A1 | Substituted azetidinones | Cadrenal Therapeutics, Inc. | 2007-05-10 | — | — | US | disclosed |
| WO-2006108039-A2 | SUBSTITUTED AZETIDINONES | DAIAMED, INC. (US) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105832-A1 | Substituted azetidinones | F2R, CPA3, CFD | CYP1A2 707/4885ALDH1A1 2503/4885CYP3A4 795/4885 |
| US-20100144698-A1 | SUBSTITUTED AZETIDINONES | F2R, CPA3, CFD | CYP1A2 707/4885ALDH1A1 2503/4885CYP3A4 795/4885 |
| US-20090143351-A1 | SUBSTITUTED AZETIDINONES | F2R, CPA3, CFD | CYP1A2 707/4885ALDH1A1 2503/4885CYP3A4 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.