Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MPI | P34949 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822477 | 0.86 | KMT2A (0.76) | KMT2APOLBTSHRSMN1; SMN2GAA | |
| SCHEMBL6034019 | 0.81 | TSHR (0.85) | KMT2APOLBTSHRCYP2D6HPGD | |
| SCHEMBL23973874 | 0.80 | POLB (0.66) | KMT2APOLBTSHRTP53HSD17B10 | |
| SCHEMBL16511117 | 0.79 | GAA (0.83) | KMT2APOLBTSHRSMN1; SMN2GAA | |
| SCHEMBL14817986 | 0.79 | POLB (0.85) | KMT2APOLBTSHRSMN1; SMN2MAPK1 | |
| SCHEMBL12460078 | 0.79 | POLB (0.65) | KMT2APOLBTSHRGAAMAPK1 | |
| SCHEMBL13096431 | 0.78 | POLB (0.64) | KMT2APOLBSMN1; SMN2GAAMAPK1 | |
| SCHEMBL2822368 | 0.78 | POLB (0.67) | KMT2APOLBTSHRSMN1; SMN2GAA | |
| SCHEMBL30673257 | 0.78 | ALDH1A1 (0.82) | KMT2APOLBSMN1; SMN2MAPK1LMNA | |
| SCHEMBL14430765 | 0.78 | KMT2A (0.64) | KMT2ATSHRSMN1; SMN2GAACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |