Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.77 |
| ▸ | GAA | P10253 | 5/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ME2 | P23368 | 5/20 | 0.55 |
| ▸ | ME1 | P48163 | 5/20 | 0.55 |
| ▸ | ME3 | Q16798 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2822446 | 0.90 | MAPT (0.77) | MAPTGAAPOLBKDM4EPKM | |
| SCHEMBL2308675 | 0.83 | MAPT (0.55) | MAPTGAAPOLBKDM4ECASP6 | |
| SCHEMBL2306481 | 0.79 | MAPT (0.65) | MAPTGAAPOLBKDM4EPKM | |
| SCHEMBL4994240 | 0.79 | GFER (0.61) | MAPTGAAKDM4EME2ME1 | |
| SCHEMBL3083321 | 0.77 | MAPT (0.71) | MAPTGAAPOLBNPC1KMT2A | |
| SCHEMBL3055201 | 0.76 | MAPT (0.63) | MAPTGAAPOLBKDM4EPKM | |
| SCHEMBL188832 | 0.75 | AKR1C3 (0.65) | MAPTGAAPOLBKDM4ERECQL | |
| SCHEMBL15650594 | 0.75 | GFER (0.65) | MAPTGAAPOLBKDM4ERECQL | |
| SCHEMBL2308856 | 0.75 | KMT2A (0.71) | MAPTGAAPOLBKDM4EPKM | |
| SCHEMBL3090713 | 0.75 | POLB (0.77) | MAPTGAAPOLBKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028776-A1 | PIPERAZINE DERIVATIVES FOR BINDING AND IMAGING AMYLOID PLAQUES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-18 | — | — | WO | disclosed |
| EP-2163541-A1 | Piperazine derivatives for binding and imaging amyloid plaques and their use | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-03-17 | — | — | EP | disclosed |