Sugi Predict

Sugi Predict / Compounds / SCHEMBL3055201

SCHEMBL3055201

SCHEMBL3055201

Nc1ccc(N2CCN(c3ccc(O)cc3)CC2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.63
▸ ALDH1A1 P00352 8/20 0.63
▸ GAA P10253 7/20 0.63
▸ LMNA P02545 6/20 0.63
▸ GFER P55789 5/20 0.63
▸ KDM4E B2RXH2 5/20 0.63
▸ KMT2A Q03164 3/20 0.63
▸ HTT P42858 2/20 0.63
▸ TDP1 Q9NUW8 2/20 0.63
▸ MAPK1 P28482 1/20 0.63
▸ ADRA2C P18825 1/20 0.63
▸ PTK2B Q14289 1/20 0.63
▸ ESR2 Q92731 1/20 0.63
▸ THRB P10828 2/20 0.59
▸ ALOX15 P16050 2/20 0.59
▸ HSD17B10 Q99714 2/20 0.59
▸ L3MBTL1 Q9Y468 2/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ NPC1 O15118 1/20 0.59
▸ USP2 O75604 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6151120 0.88 MAPT (0.77) MAPTALDH1A1GAALMNAGFER
SCHEMBL23347931 0.88 MAPT (0.77) MAPTALDH1A1GAALMNAGFER
SCHEMBL7043679 0.88 MAPT (0.77) MAPTALDH1A1GAALMNAGFER
SCHEMBL7041242 0.88 MAPT (0.68) MAPTALDH1A1GAALMNAGFER
SCHEMBL7106841 0.81 KDM4E (0.61) MAPTALDH1A1GAALMNAGFER
SCHEMBL112440 0.81 MAPT (0.78) MAPTALDH1A1GAALMNAGFER
Hydrochloric Acid SCHEMBL5169602 0.79 MAPT (0.83) MAPTALDH1A1GAALMNAGFER
SCHEMBL12952701 0.79 MAPT (0.65) MAPTALDH1A1GAALMNAGFER
SCHEMBL8931737 0.79 DRD4 (0.67) MAPTALDH1A1GAALMNAGFER
SCHEMBL657027 0.78 ALDH1A1 (0.57) MAPTALDH1A1GAALMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114516849-B Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 江苏恒盛药业有限公司 2025-04-29 — — CN claimed
CN-111362886-B Preparation method of posaconazole intermediate 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 四川澄华生物科技有限公司 2023-05-16 — — CN claimed
CN-114516849-A Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 江苏恒盛药业有限公司 2022-05-20 — — CN claimed
CN-114276315-A Preparation method of 4- [4- [4- (4-hydroxyphenyl) piperazine-1-yl ] phenyl carbamate 苏州汉德创宏生化科技有限公司 2022-04-05 — — CN claimed
CN-110437463-B Dendritic polymer, preparation method and application thereof 威海晨源分子新材料有限公司 2022-01-21 — — CN claimed
CN-106366310-B Carboxyl-containing high-refractive-index hyperbranched polyesteramide, preparation method thereof and application thereof in plastic modification 威海晨源分子新材料有限公司 2020-09-08 — — CN claimed
CN-111362886-A Preparation method of posaconazole intermediate 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 成都百特万合医药科技有限公司 2020-07-03 — — CN claimed
CN-110437463-A Dendritic, preparation method and its application WEIHAI CY DENDRIMER TECH CO LTD 2019-11-12 — — CN claimed
CN-108003118-A A kind of posaconazole intermediate 1-（4- hydroxy phenyls）-4-（4- aminophenyls）The preparation process of-piperazine 张家口市格瑞高新技术有限公司 2018-05-08 — — CN claimed
EP-2758385-B1 PROCESS FOR THE PREPARATION OF TRIAZOLE ANTIFUNGAL DRUG, ITS INTERMEDIATES AND POLYMORPHS THEREOF MSN LAB LTD (IN) 2018-03-28 — — EP claimed
US-20140343285-A1 Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof MSN LABORATORIES LIMITED (IN) 2014-11-20 — — US claimed
EP-2758385-A2 PROCESS FOR THE PREPARATION OF TRIAZOLE ANTIFUNGAL DRUG, ITS INTERMEDIATES AND POLYMORPHS THEREOF MSN Laboratories Limited (IN) 2014-07-30 — — EP claimed
WO-2013042138-A2 PROCESS FOR THE PREPARATION OF TRIAZOLE ANTIFUNGAL DRUG, ITS INTERMEDIATES AND POLYMORPHS THEREOF MSN LABORATORIES LIMITED (IN) 2013-03-28 — — WO claimed
CN-101824009-A Simple preparation method for posaconazole and piperazine intermediate thereof BEIJING DVENTUREPHARM TECHNOLOGY DEV CO LTD 2010-09-08 — — CN claimed
CN-114516849-B Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 江苏恒盛药业有限公司 2025-04-29 — — CN disclosed
CN-114516849-B Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 江苏恒盛药业有限公司 2025-04-29 — — CN disclosed
CN-114516849-B Synthesis method of 1- (4-aminophenyl) -4- (4-hydroxyphenyl) piperazine 江苏恒盛药业有限公司 2025-04-29 — — CN disclosed
US-4368200-A BACTERICIDES, FUNGICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1983-01-11 — — US disclosed
US-4267179-A AS FUNGICIDES AND BACTERICIDES JANSSEN PHARMACEUTICA, N.V. (BE) 1981-05-12 — — US disclosed
EP-0006711-A1 Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles, processes for preparing them and compositions containing them JANSSEN PHARMACEUTICA N.V. (BE) 1980-01-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140343285-A1 Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof CYP3A4, CYP51A1, CYP1B1 MAPT 1385/4885ALDH1A1 372/4885GAA 505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.