Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28226184 | 0.90 | RAB9A (0.47) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28225444 | 0.90 | SIRT2 (0.41) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28225445 | 0.87 | EGFR (0.38) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28860832 | 0.87 | SIRT2 (0.43) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28225440 | 0.87 | IDO1 (0.46) | EGFRPIK3CARAB9ASMN1; SMN2LMNA | |
| SCHEMBL28053874 | 0.79 | EGFR (0.62) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16402186 | 0.79 | EGFR (0.44) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28053768 | 0.77 | NPC1 (0.43) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28225463 | 0.77 | NPC1 (0.43) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28860919 | 0.73 | RXFP1 (0.40) | EGFRPIK3CARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105283443-B | Hete rocyclic derivatives and application thereof | 株式会社C&C新药研究所 | 2018-08-17 | — | — | CN | claimed |
| CN-105283443-B | Hete rocyclic derivatives and application thereof | 株式会社C&C新药研究所 | 2018-08-17 | — | — | CN | disclosed |