Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CNR2 | P34972 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | PDE6D | O43924 | 1/20 | 0.60 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022127 | 0.95 | TP53 (0.75) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8021696 | 0.87 | MAPT (0.61) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL10443667 | 0.84 | ALDH1A1 (0.82) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8027362 | 0.84 | KDM4E (0.79) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18890616 | 0.83 | MAPT (0.61) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18890598 | 0.82 | MAPT (0.63) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL23361809 | 0.82 | CSF1R (0.76) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL4089473 | 0.82 | MAPT (0.63) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL30897373 | 0.82 | POLB (0.61) | TP53MAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29412044 | 0.80 | TP53 (1.00) | TP53MAPTSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250202-B | 2,3- disubstituted benzenes and imidazo [1,2-a] pyrimidines and its preparation method and application | 陕西师范大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-108250202-A | 2,3- disubstituted benzenes and imidazo [1,2-a] pyrimidines and its preparation method and application | 陕西师范大学 | 2018-07-06 | — | — | CN | disclosed |