SCHEMBL28228565

SCHEMBL28228565

Cc1cnn(Cc2ccc(Cn3cc(C(=O)O)c(Br)n3)cc2)c1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 19/20 0.52
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16246824 0.87 KLKB1 (0.59) KLKB1HSD17B10
SCHEMBL16246700 0.86 KLKB1 (0.49) KLKB1
SCHEMBL16247180 0.86 KLKB1 (0.53) KLKB1HSD17B10
SCHEMBL16246898 0.85 KLKB1 (0.57) KLKB1
SCHEMBL16246944 0.84 KLKB1 (0.55) KLKB1
SCHEMBL16246939 0.82 KLKB1 (0.58) KLKB1HSD17B10
SCHEMBL16246770 0.81 KLKB1 (0.57) KLKB1HSD17B10
SCHEMBL16246844 0.81 ALDH1A1 (0.62) KLKB1HSD17B10
SCHEMBL16246727 0.81 KLKB1 (0.59) KLKB1
SCHEMBL16247001 0.81 KLKB1 (0.72) KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105452240-B Hete rocyclic derivatives 卡尔维斯塔制药有限公司 2018-06-26 CN disclosed