Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 3/20 | 0.54 |
| ▸ | CCND1 | P24385 | 3/20 | 0.54 |
| ▸ | CCND2 | P30279 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492001 | 0.88 | SYK (0.62) | LCKMAPK14KDRALKBRD4 | |
| SCHEMBL28228708 | 0.84 | SYK (0.54) | SYKCDK4CCND1CCND2CCND3 | |
| SCHEMBL4721744 | 0.83 | LCK (0.81) | LCKMAPK14KDRBRD4NPC1 | |
| SCHEMBL31163120 | 0.83 | BRD4 (0.75) | BRD4EGFR | |
| SCHEMBL19496537 | 0.81 | LCK (0.59) | LCKMAPK14KDRALKBRD4 | |
| SCHEMBL29037749 | 0.81 | ALK (0.69) | LCKMAPK14ALKBRD4EGFR | |
| SCHEMBL29037828 | 0.81 | EGFR (0.60) | ALKBRD4EGFRSYKCDK4 | |
| SCHEMBL2961783 | 0.81 | EGFR (0.60) | LCKMAPK14KDRALKEGFR | |
| SCHEMBL2951233 | 0.81 | ALK (0.62) | LCKMAPK14ALKBRD4EGFR | |
| SCHEMBL30463630 | 0.81 | ALK (0.65) | LCKMAPK14KDRALKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299312-A | One group of pyridine derivatives and its application in preparation of anti-tumor drugs | 郑州大学第附属医院 | 2018-07-20 | — | — | CN | disclosed |