Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 9/20 | 0.52 |
| ▸ | CCND1 | P24385 | 5/20 | 0.52 |
| ▸ | CCND3 | P30281 | 4/20 | 0.52 |
| ▸ | CCND2 | P30279 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488495 | 0.88 | SYK (0.62) | SYKSTAT6MAPK8MAPK9MAPK10 | |
| SCHEMBL28228697 | 0.84 | LCK (0.60) | SYKSTAT6CDK4CCND1CCND3 | |
| SCHEMBL21275499 | 0.79 | PLK4 (0.57) | MAPK8MAPK9CDK4CCND1CDK2 | |
| SCHEMBL30459671 | 0.77 | CDK4 (0.53) | STAT6CDK4CCND1CCND3CCND2 | |
| SCHEMBL598515 | 0.76 | ALDH1A1 (0.72) | ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL28227975 | 0.75 | SYK (0.48) | SYKSTAT6MAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL4652111 | 0.75 | ALDH1A1 (0.70) | ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL7064739 | 0.74 | SYK (0.60) | SYKSTAT6MAPK8MAPK9MAPK10 | |
| SCHEMBL3590138 | 0.74 | PDGFRB (0.62) | SYKSTAT6CDK4CCND1CCND3 | |
| SCHEMBL598464 | 0.74 | POLB (0.65) | ALDH1A1USP2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299312-A | One group of pyridine derivatives and its application in preparation of anti-tumor drugs | 郑州大学第附属医院 | 2018-07-20 | — | — | CN | disclosed |