Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18456841 | 0.85 | POLB (0.66) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL28229464 | 0.83 | MEN1 (0.46) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL8221788 | 0.81 | POLB (0.68) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL10272620 | 0.76 | POLB (0.69) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL18641427 | 0.75 | POLB (0.56) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL18641455 | 0.75 | POLB (0.56) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL3138985 | 0.75 | POLB (1.00) | POLBMEN1KMT2AABL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL18641553 | 0.74 | POLB (0.58) | POLBMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL18067938 | 0.73 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL10220130 | 0.72 | POLB (0.64) | POLBMEN1KMT2AABL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106699682-B | N- (4- alkyl -5- benzyls thiazol-2-yl) amino alkane amide and the preparation method and application thereof | 湖南大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-106467498-B | N- (thiazol-2-yl) aminoamide derivatives and the preparation method and application thereof | 湖南大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-106938989-B | N- (5- benzyls thiazol-2-yl) acetamide derivative and the preparation method and application thereof | 湖南大学 | 2018-09-07 | — | — | CN | disclosed |