Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.67 |
| ▸ | MMP2 | P08253 | 3/20 | 0.67 |
| ▸ | MMP14 | P50281 | 2/20 | 0.67 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | BCR | P11274 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 10/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28546975 | 0.93 | SYK (0.58) | MMP13MMP2MMP14NR4A1SYK | |
| SCHEMBL28371930 | 0.85 | NR4A1 (0.67) | NR4A1ABL1BCRSRCSYK | |
| SCHEMBL28553674 | 0.84 | SYK (0.53) | MMP13MMP2SYK | |
| SCHEMBL28542880 | 0.83 | SYK (0.54) | MMP13ABL1SYK | |
| SCHEMBL28377494 | 0.83 | NR4A1 (0.83) | NR4A1ABL1BCRSRCSYK | |
| SCHEMBL28536173 | 0.82 | MMP13 (0.52) | MMP13MMP2NR4A1SYK | |
| SCHEMBL28376014 | 0.81 | ABL1 (0.67) | NR4A1ABL1BCRSRCSYK | |
| SCHEMBL3947629 | 0.81 | ABL1 (0.62) | ABL1BCRSRCPRKCA | |
| SCHEMBL28536169 | 0.81 | NR4A1 (0.65) | NR4A1ABL1BCRSRCSYK | |
| SCHEMBL28375479 | 0.81 | NR4A1 (0.65) | NR4A1ABL1BCRSRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734708-B | Pyrimidine indole Nur77 receptor regulator and preparation method and application thereof | 厦门大学 | 2021-04-09 | — | — | CN | disclosed |
| CN-107739368-B | N-substituted-5- ((4-substituted pyrimidine-2-yl) amino) indole derivatives, and preparation method and application thereof | 厦门大学 | 2020-02-14 | — | — | CN | disclosed |
| CN-104829597-B | 1H- indoles -2- carbohydrazide derivatives and its preparation method and application | 厦门大学 | 2018-07-17 | — | — | CN | disclosed |