Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.62 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27141104 | 0.98 | CYP2D6 (0.72) | CYP2D6GNAI3USP2APOBEC3ACTDSP1 | |
| SCHEMBL591547 | 0.97 | CYP2D6 (0.74) | CYP2D6GNAI3USP2APOBEC3ACTDSP1 | |
| SCHEMBL18753807 | 0.91 | CYP2D6 (0.67) | CYP2D6GNAI3USP2APOBEC3ACTDSP1 | |
| Hydrochloric Acid SCHEMBL27146677 | 0.84 | KDM4E (0.67) | CYP2D6GNAI3USP2CHRM2MEN1 | |
| SCHEMBL8401996 | 0.83 | CYP1A2 (0.76) | CYP2D6GNAI3USP2APOBEC3ACTDSP1 | |
| SCHEMBL31464092 | 0.82 | KDM4E (0.69) | CYP2D6GNAI3USP2CHRM2MEN1 | |
| SCHEMBL13284339 | 0.82 | MEN1 (0.79) | CYP2D6GNAI3USP2CHRM2MEN1 | |
| SCHEMBL10894451 | 0.81 | CYP2D6 (0.62) | CYP2D6GNAI3USP2CHRM2MEN1 | |
| SCHEMBL8672312 | 0.81 | SIGMAR1 (0.79) | CYP2D6GNAI3USP2SLC6A4KCNH2 | |
| SCHEMBL11033419 | 0.81 | MAPT (0.65) | CYP2D6GNAI3USP2LMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329282-A | A kind of phenylpiperazine analog derivative and its preparation method and application | 新乡医学院 | 2018-07-27 | — | — | CN | disclosed |