Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.47 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282500 | 0.87 | BCL2 (0.52) | BCL2PTPN1HDAC8PPARAATM | |
| SCHEMBL10726110 | 0.84 | MME (0.54) | BCL2HDAC8REN | |
| SCHEMBL10726098 | 0.84 | MME (0.54) | BCL2HDAC8REN | |
| SCHEMBL19930027 | 0.84 | BCL2 (0.59) | BCL2PTPN1HDAC8PPARAATM | |
| SCHEMBL12532786 | 0.84 | BCL2 (0.59) | BCL2PTPN1HDAC8PPARAATM | |
| SCHEMBL2891538 | 0.83 | PTPN1 (0.73) | BCL2PTPN1HDAC8PPARAYAP1 | |
| SCHEMBL193474 | 0.83 | PTPN1 (0.73) | BCL2PTPN1HDAC8PPARAYAP1 | |
| SCHEMBL193473 | 0.83 | PTPN1 (0.73) | BCL2PTPN1HDAC8PPARAYAP1 | |
| SCHEMBL272806 | 0.82 | ATM (0.59) | BCL2PTPN1HDAC8PPARAATM | |
| SCHEMBL272406 | 0.82 | ATM (0.59) | BCL2PTPN1HDAC8PPARAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689383-B1 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |