Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28599304 | 0.97 | — | — | |
| SCHEMBL491816 | 0.94 | — | — | |
| SCHEMBL28265339 | 0.92 | — | — | |
| SCHEMBL28061710 | 0.89 | LMNA (0.40) | LMNATSHRALDH1A1TP53HIF1A | |
| Benzene SCHEMBL28123308 | 0.89 | LMNA (0.40) | LMNATSHRALDH1A1TP53HIF1A | |
| SCHEMBL7076062 | 0.82 | TSHR (0.43) | LMNATSHRALDH1A1TP53HIF1A | |
| SCHEMBL10429566 | 0.81 | LMNA (0.38) | LMNATSHRALDH1A1TP53HIF1A | |
| SCHEMBL27987249 | 0.79 | TSHR (0.42) | LMNATSHRALDH1A1TP53HIF1A | |
| SCHEMBL278164 | 0.78 | — | — | |
| SCHEMBL5694525 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108326229-A | A kind of high intensity releasing agent and preparation method thereof | 苏州捷德瑞精密机械有限公司 | 2018-07-27 | — | — | CN | claimed |