Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24922507 | 0.77 | ADORA2A (0.46) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL46317 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL31516755 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL3462062 | 0.77 | LMNA (0.57) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL10754057 | 0.77 | CXCR4 (0.53) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL19796113 | 0.76 | NAMPT (0.50) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL11117073 | 0.75 | NOTUM (0.58) | KDM4EALDH1A1RXFP1KMT2AMEN1 | |
| SCHEMBL23957682 | 0.75 | LMNA (0.48) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL2728318 | 0.74 | LMNA (0.57) | KDM4EALDH1A1RXFP1LMNAKMT2A | |
| SCHEMBL22925970 | 0.74 | LMNA (0.57) | KDM4EALDH1A1RXFP1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881683-A | PI3K alpha inhibitors and methods of use thereof | 传达治疗有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-116730978-A | Compound containing heteroaromatic ring alkynyl, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-09-12 | — | — | CN | disclosed |
| CN-114702495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-108473495-B | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-108473495-A | Purinones as ubiquitin-specific protease 1 inhibitors | 福马治疗有限公司 | 2018-08-31 | — | — | CN | disclosed |