Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.45 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28228302 | 0.80 | MAPT (0.64) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL16039236 | 0.79 | MAPT (0.67) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28228303 | 0.78 | MAPT (0.64) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1957773 | 0.78 | SMN1; SMN2 (0.69) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28252139 | 0.77 | MAPT (0.68) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28817461 | 0.77 | MAPT (0.68) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1958584 | 0.77 | MAPT (0.75) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28817474 | 0.76 | MAPT (0.67) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28817471 | 0.76 | MAPT (0.67) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL28817463 | 0.76 | MAPT (0.67) | MAPTPKMPOLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109966294-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109897038-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-106008322-B | sulfonamide derivatives as BC L-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2018-09-04 | — | — | CN | disclosed |