Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | IDH2 | P48735 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28139467 | 0.85 | MAPK9 (0.41) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10094582 | 0.82 | MAPK9 (0.43) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30388994 | 0.78 | HTT (0.44) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2563638 | 0.77 | MAPK9 (0.41) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1914533 | 0.77 | L3MBTL1 (0.54) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6792166 | 0.76 | L3MBTL1 (0.52) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4660326 | 0.73 | MAPK9 (0.39) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13991756 | 0.73 | MAPK9 (0.39) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8509282 | 0.73 | MAPK9 (0.39) | GAALMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23206269 | 0.72 | IDH1 (0.36) | LMNAALDH1A1KMT2AIDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105263929-B | 3-Pyrimidin-4-yl-oxazolidin-2-one compounds as mutant IDH inhibitors | 诺华股份有限公司 | 2018-08-28 | — | — | CN | disclosed |