Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 3/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetamide SCHEMBL9870183 | 0.94 | LMNA (0.55) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinamide SCHEMBL27602218 | 0.91 | LMNA (0.64) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinamide SCHEMBL27602217 | 0.91 | LMNA (0.64) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL30870384 | 0.91 | LMNA (0.64) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| SCHEMBL36056 | 0.91 | — | — | |
| Succinamide SCHEMBL27460624 | 0.91 | FFAR3 (0.50) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinamide SCHEMBL1864469 | 0.91 | LMNA (0.64) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Succinamide SCHEMBL28644546 | 0.91 | FFAR3 (0.50) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| SCHEMBL27395431 | 0.89 | LMNA (0.50) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| SCHEMBL28087102 | 0.88 | LMNA (0.53) | LMNASLC15A2EGLN1ALKBH5SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368176-A | Anti- TIGIT antigen-binding proteins and its application method | 波滕扎治疗公司 | 2018-08-03 | — | — | CN | disclosed |