Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.72 |
| ▸ | TYMS | P04818 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 5/20 | 0.51 |
| ▸ | GART | P22102 | 2/20 | 0.48 |
| ▸ | ATIC | P31939 | 1/20 | 0.48 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.45 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.45 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414575 | 0.90 | AKR1B1 (0.76) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL8768808 | 0.90 | AKR1B1 (0.76) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL7990867 | 0.89 | TYMS (0.77) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL15094347 | 0.89 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30174303 | 0.89 | AKR1B1 (0.81) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL30097384 | 0.88 | TYMS (0.80) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL28226859 | 0.88 | AKR1B1 (0.80) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL5427454 | 0.88 | AKR1B1 (0.72) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL15870445 | 0.87 | TYMS (0.79) | AKR1B1TYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL869875 | 0.87 | AKR1B1 (0.79) | AKR1B1TYMSKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111333786-B | Preparation method of acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting | 苏州大学 | 2023-01-06 | — | — | CN | claimed |
| CN-111333786-A | Preparation method of acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting | 苏州大学 | 2020-06-26 | — | — | CN | claimed |
| CN-108524529-B | Acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting as well as preparation method and application thereof | 苏州大学 | 2020-05-22 | — | — | CN | claimed |
| CN-108524529-A | Acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting as well as preparation method and application thereof | 苏州大学 | 2018-09-14 | — | — | CN | claimed |
| CN-111333786-B | Preparation method of acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting | 苏州大学 | 2023-01-06 | — | — | CN | disclosed |
| CN-111333786-A | Preparation method of acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting | 苏州大学 | 2020-06-26 | — | — | CN | disclosed |
| CN-108524529-B | Acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting as well as preparation method and application thereof | 苏州大学 | 2020-05-22 | — | — | CN | disclosed |
| CN-108524529-A | Acid-sensitive adriamycin prodrug based on zwitterion and folic acid targeting as well as preparation method and application thereof | 苏州大学 | 2018-09-14 | — | — | CN | disclosed |